Cell Cycle and Cell Division

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Summary

This chapter explains how cells reproduce through the cell cycle and the two kinds of division, mitosis and meiosis. The cell cycle is the orderly sequence by which a cell duplicates its genome, synthesises other constituents and divides; in a typical human cell it lasts about 24 hours. It has two basic phases: interphase, which occupies over 95 per cent of the cycle and is subdivided into G1 (growth without DNA replication), S (DNA replication, when DNA content doubles though chromosome number stays the same) and G2 (preparation for mitosis), and the M phase (mitosis). Cells that stop dividing enter a quiescent G0 stage. Mitosis, the equational division, keeps the chromosome number constant and proceeds through prophase (chromosome condensation, spindle formation), metaphase (chromosomes align on the metaphase plate), anaphase (centromeres split and chromatids move to poles) and telophase (nuclei reform), followed by cytokinesis (a furrow in animal cells, a cell plate in plant cells). Meiosis, the reductional division, occurs in diploid cells that form gametes; it has two divisions but one round of DNA replication. Meiosis I includes a long prophase I (leptotene, zygotene, pachytene with crossing over, diplotene and diakinesis), and meiosis II resembles mitosis, yielding four haploid cells. Mitosis enables growth and repair; meiosis conserves chromosome number across generations and generates variation.

Phases of the cell cycle: G1, S, G2M phase and the quiescent G0 stageMitosis: prophase to telophaseCytokinesis and significance of mitosisMeiosis I and prophase I sub-stagesMeiosis II and significance of meiosis

Key terms

Cell cycle
The sequence of events by which a cell duplicates its genome and divides into two daughter cells.
Interphase
The phase between two M phases, comprising G1, S and G2, during which the cell grows and replicates its DNA.
Mitosis
The equational division of a cell into two daughter cells with the same chromosome number as the parent.
Meiosis
The reductional division that halves the chromosome number and produces four haploid cells.
Crossing over
The exchange of genetic material between non-sister chromatids of homologous chromosomes during pachytene.
Cytokinesis
The division of the cytoplasm following nuclear division, completing cell division.

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DNA replication during the cell cycle takes place in the:
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